Devanagari letter र (R, more precisely ra in IAST or ISO 15919) and letter स (S, sa) are somewhat similar. The similarity is more apparent when comparing rā with sa:
What is the history and nature of this similarity (if not random)?
Earlier forms of the script such as Brahmi 𑀭 = r, 𑀲 = s as well as related script (Gurmukhi ਰ = r, ਸ = s), reveal that it is a coincidence. It is interesting to note that Tibetan ར = r, ས = s which are are significantly similar to Devanagari, but Bengali র = r, স = s which are not so similar. Yet Tibetan and Bengali scripts are classified as examples of Siddham scripts. The drawings in that page suggest that the seeds of similarity were present in that script, and developed independently in Devanagari and Tibetan.