In some sign languages, pointing is used as a pronoun. It makes different distinctions to the ones made by English pronouns.
In English, he, she, this, that and it are different. He and him are different. These distinctions are not made in the sign languages of English speaking countries.
Instead, you can point directly at a person or thing instead of using its name. That provides as many distinct pronouns as there are things or people that are mutually visible to the speaker and audience.
If Alice points at Bob, then Bob would translate that into English as "you" and Charlie would translate it as "him" but unlike an English "you" or "him", everyone who saw it would unambiguously know that it is about Bob and Bob only.
In ASL, BSL and Auslan, pointing with the index finger is I/you/he/she/that and so on, and there's a way to point with the palm for the possessive pronoun.
In a sign language you may also be able to point at a location in empty space as a pronoun that means "the person or thing I talked about after I pointed here" or "the person or thing I talked about while my hands were over here". This provides a few pronouns that can distinguish in context a small number of different subjects that aren't mutually visible.
For "John hates James, he's rude" in Auslan Alice could sign "right James, left John hates, he's rude" and she could indicate whether James or John is the rude one by signing the "he" to the left or right. ASL might have different word order to this example (I don't know) but a similar principle would apply.
This link gives specific information about pronouns in ASL, with videos.
BSL and Auslan are very very different languages to ASL but some of the pronouns are the same in all three.